關於「Does tRNA inhibit protein synthesis」標籤，搜尋引擎有相關的訊息討論：

tRNAs as Antibiotic Targets - NCBI。

This essential and ubiquitous nature of tRNAs in protein synthesis make them ... a stop codon is encountered leading to the termination stage of translation ...： tw | tw。

Discovery and Analysis of Natural-Product Compounds Inhibiting ...。

Fusidic acid is an antibiotic that inhibits protein synthesis by trapping EF-G ... Indirectly, the amino-acyl tRNA synthetases (aaRS) are essential enzymes ...： tw | tw。

Nascent peptides that block protein synthesis in bacteria | PNAS。

2013年3月5日 · In other stalling motifs, peptidyl transfer to certain aminoacyl-tRNAs is inhibited. In particular, three consecutive Pro codons pose a ...： tw | tw。

Progress and challenges in aminoacyl-tRNA synthetase-based ...。

Given the essentiality of protein synthesis to the survival and fitness of living cells, it is not surprising that the translation apparatus represents one ...。

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by ...。

2013年6月12日 · Abstract. Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited ...。

Discovery of Novel Oral Protein Synthesis Inhibitors of ...。

2016年9月23日 · Leucyl-tRNA synthetase (LeuRS) is a class I AARS that has two active sites separated by a distance of 30 Å, a synthetic site that aminoacylates ...。

The protein translation machinery is expressed for maximal ... - Nature。

2020年10月16日 · Here, we show that the growth rate-dependence of the concentrations of ribosomes, tRNAs, mRNA, and elongation factors observed in Escherichia ...。

Inhibition of Protein Synthesis by Antibiotics - Sigma-Aldrich。

Hygromycin B is an aminoglycoside that specifically binds to a single site within the 30S subunit in a region that contains the A, P, and E sites of tRNA. It ...： 。

Full article: Drugging tRNA aminoacylation - Taylor & Francis Online。

However, design of novel aminoacylation inhibitors is complicated by the steadfast requirement to avoid off-target inhibition of protein synthesis in human ...。

Transfer RNA - Wikipedia。

This type of engineered tRNA is called a nonsense suppressor tRNA because it suppresses the translation stop signal that normally occurs at UAG codons. The ...