關於「Glucosylceramide synthase」標籤，搜尋引擎有相關的訊息討論：

Ceramide Glycosylation Catalyzed by Glucosylceramide Synthase ...。

As ceramide glycosylation by GCS is a rate-limiting step in GSL synthesis, inhibition of GCS sensitizes cancer cells to anticancer drugs and eradicates cancer ...： tw | tw。

Glucosylceramide is Critical for Cell-Type Differentiation and ... - NCBI。

GlcCer are formed by activity of an evolutionarily conserved glucosylceramide synthase (GCS) that catalyzes the transfer of Glc from UDP-Glc to ceramide ...： tw | tw。

CNS-accessible Inhibitor of Glucosylceramide Synthase for ...。

2016年4月5日 · SRT for GD acts through inhibition of glucosylceramide synthase (GCS) to reduce the production of the substrates GL-1 and lyso-GL-1 that ...： tw | tw。

Glucosylceramide synthase deficiency in the heart compromises β1 ...。

2021年7月23日 · Ugcgfl/fl mice,24 in which exons 6 and 7 were flanked with loxP sites, and α-myosin heavy chain (α-MHC)-Cre mice (stock no. 009074, Jackson ...。

Systemic Delivery of a Glucosylceramide Synthase Inhibitor ... - PLOS。

2012年8月17日 · Figures 1A and 1B show that in WT mouse brain, the predominant GL-1 isomer in the first few days of life was GluCer; by postnatal day 14 (P14) ...。

Glucosylceramide Synthases, a Gene Family Responsible for the ...。

Lynch D.V.. Moore Jr., T.S. Lipid Metabolism in Plants. CRC Press, Inc., Boca Raton, FL1993 ...： tw | tw。

A Study of Glucosylceramide Synthase and Glycolytic Pathway ...。

We measured gene expression levels of glucosylceramide synthase and of glycolytic ... Link: https://goo.gl/6frWC3; Bain BJ, Fletcher SH (2007) Chronic ...： tw | tw。

Venglustat | ALZFORUM。

2021年7月19日 · GCS catalyzes an early step in the synthesis of many glycolipids. ... Target engagement was deemed successful: glucosylceramide GL-1 levels ...。

Efficacy of Enzyme and Substrate Reduction Therapy with a Novel ...。

2015年4月30日 · ... a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease ... For the extraction of GL-3 and lyso-GL-3, the solvents consisted ...。

Incorporation of Fluorescence Ceramide-Based HPLC Assay for ...。

2017年6月7日 · Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ... Images (200× magnification) were captured using an EVOS FL cell ...