關於「HUWE1 cancer」標籤，搜尋引擎有相關的訊息討論：

Ubiquitination by HUWE1 in tumorigenesis and beyond - Journal of ...。

2018年9月4日 · HUWE1 is a multifaceted HECT domain-containing ubiquitin E3 ligase, ... HUWE1 is a critical ubiquitination modulator during the tumor ...。

HUWE1 controls the development of non-small cell lung cancer ...。

2018年6月6日 · The E3 ligase HUWE1, which targets many tumor-associated proteins including p53, has been reported to be highly expressed in lung cancer; ...： tw | tw。

HUWE1 is a critical colonic tumour suppressor gene that prevents ...。

Functionally inactivating HUWE1 mutations are present in primary colorectal cancer samples. Genetic deletion of Huwe1 in an Apc heterozygous mouse model leads ... Skip main navigation · Results · Discussion · Materials and Methods。

[PDF] A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity - MDPI。

2021年5月20日 · Recently, a bladder cancer genome-wide CRISPR/Cas9 knock- ... hits was the HECT domain-containing ubiquitin E3 ligase (HUWE1).。

Meta‑analysis of gene expression alterations and clinical ...。

2019年7月5日 · Expression levels of HUWE1 in cancer vs. normal tissues were ... McKenna WG and Dianov GL: Ubiquitin ligase ARF-BP1/Mule modulates base ...。

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by ...。

Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or senescence ...。

Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and ...。

2017年9月15日 · Inducible silencing of HUWE1 in human ovarian cancer ... of skin cancer, deleting the Huwe1 gene accelerated tumor devel-.。

A conformational switch regulates the ubiquitin ligase HUWE1 | eLife。

2017年2月14日 · The cancer-associated human ubiquitin ligase HUWE1 can adopt an ... a Superdex 200 10/300 GL column (GE Healthcare) coupled to a Dawn 8+ ...。

Direct regulation of Chk1 protein stability by E3 ubiquitin ligase ...。

2019年11月11日 · Indeed, some of the HUWE1 substrates are oncoproteins, suggesting HUWE1 functions as a tumor suppressor, while other substrates are tumor ...： tw | tw。

DNA damage-induced activation of CUL4B targets HUWE1 for ...。

2015年4月16日 · The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in ... for cancer therapy by targeting HUWE1 and the CUL4B E3 ligase.